2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3349-53. doi: 10.1016/j.bmcl.2007.03.102. Epub 2007 Apr 5.

Abstract

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Binding, Competitive
  • Cytomegalovirus / drug effects*
  • DNA-Directed DNA Polymerase
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use
  • Ethylamines / chemical synthesis
  • Ethylamines / pharmacology*
  • Exodeoxyribonucleases / antagonists & inhibitors*
  • Herpes Zoster / drug therapy
  • Herpesviridae / drug effects*
  • Herpesviridae / enzymology
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 4, Human / drug effects*
  • Humans
  • Models, Chemical
  • Nucleic Acid Synthesis Inhibitors*
  • Pyridines / chemical synthesis
  • Pyridines / pharmacology*
  • Structure-Activity Relationship
  • Viral Proteins / antagonists & inhibitors*

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Ethylamines
  • Nucleic Acid Synthesis Inhibitors
  • Pyridines
  • Viral Proteins
  • DNA-Directed DNA Polymerase
  • Exodeoxyribonucleases
  • DNA polymerase, Simplexvirus